This study examined the extent to which there exist workplace stress in the University of Uyo and the level of correlation between work place stress and performance by staff of the university. Using a sample of 50 academic staff and 100 non academic staff randomly selected from the 12 faculties of the University of Uyo and two instruments entitled “Workplace Stress Measurement Questionnaire” (WPSMQ) and “Job Performance Assessment Performa” (JPAP), data were collected on academic staff and non-academic staff’s psychological and behavioural stress and job performance. The study employed Pearson’s Product Moment Correlation Co-efficient to test formulated hypotheses. Findings of the study showed that academic staff experienced excess stress in academic activities as a result of work load while the non-academic staff also experienced stress in administrative and clerical responsibilities as a result of shortage of staff in the institution. Also job performance was negatively affected by the excess work stress. Among the recommendations made by the study was the need for periodic body exercise for the staff in order to reduce in effect of stress on the staff and secondly, introduction courses for academic and non-academic staff on stress management and employment of more staff to reduce the excessive work load of the staff.